新的抗凝药物─—水蛭肽的研究进展

被引:18
作者
刘刚
机构
[1] 军事医学科学院!北京,
关键词
水蛭肽; 凝血酶; 凝血酶抑制剂;
D O I
10.13220/j.cnki.jipr.1995.03.002
中图分类号
R973 [血液和造血系统药物];
学科分类号
1007 ;
摘要
水蛭素是迄今发现的凝血酶最强的天然选择性特异抑制剂。模仿水蛭素与凝血酶相互作用的机制而合成的水蛭肽类化合物取得了进展。
引用
收藏
页码:133 / 138
页数:6
相关论文
共 14 条
[1]  
The development of hirudin as anantithrombotic drug. Markwardt F. Thrombosis Research . 1994
[2]  
Chimericantithrombin peptide.Characterization of an Arg-Gly-Asp (RGD)-and hirudin carboxyl terminus-containing synthetic peptide. Church FC,Phillips JE and Woods JL. Journal of Biological Chemistry . 1991
[3]  
Synthesisof a homologous series of ketomethylene arginylpseudodipeptides and application to low molecularweight hirudin-like thrombin inhibitors. DiMaio J,Gibbs B,Lefebvre J,et al. Journal of Medicinal Chemistry . 1992
[4]  
Interac-tion of hirudin with thrombin: identification of aminimal binding domain of hirudin that inhibitsclotting activity. Mao SJT,Yates MT,Owen TJ,et al. Biochemistry . 1988
[5]  
Inhibition of in vitro clotgrowth by r-hirudin is more effective and longersustained than by an analogous peptide. Romisch J,Stohr H-A. Thrombosis and Haemostasis . 1994
[6]  
Design and characterization of hirulogs: a novelclass of bivalent peptide inhibitors of thrombin. Maraganore JM,Bourdon P,Jablonski J,et al. Biochemistry . 1990
[7]  
Thecomplete amino acid sequence of hirudin, athrombin specific inhibitor. Dodt J,Muller HP,Seemuller U,et al. FEBS Letters . 1984
[8]  
Hirudin C-terminal fragments inhibit thrombin induced neu-trophil chemotaxis. Rowand JK,Marucha P,Berliner LJ. Thrombosis and Haemostasis . 1992
[9]  
Antithrombotic effects of synthetic peptidei tar-geting various functional domains of thrombin. Kelly AB,Maraganore JM,pourdon P,et al. Proceedings of the National Academy of Sciences of the United States of America . 1992
[10]  
Antith-rombin activity of the hirudin N-terminal core do-main residues 1-43. Chang J-Y,Schlaeppi J-M,Stone SR. FEBS Letters . 1990