血栓素A2和前列腺环素与自发性高血压大鼠高血压发展的关系

被引：18

作者：

杨国雄

张国忠

李保罗

机构：

[1] 贵阳医学院病理生理教研室,贵阳医学院病理生理教研室,贵阳医学院病理生理教研室

来源：

中国病理生理杂志 | 1991年 / 03期

关键词：

血栓素A2; 前列腺素X类; 高血压; 大鼠;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

本文观察了SHR和WKY及不同年龄SHR动脉血浆中TXA2和PGI2的稳定代谢产物TXB2和6-Keto-PGF1α的浓度及其比值变化。结果表明,SHR血浆中的TXB2浓度显著高于WKY,对照组与实验组相比（207.1±59.8比1217.9±298.5P8/ml,P<0.001）,而血浆中6-Keto-PGF1α浓度,除高年龄组SHR外,其他各组均无明显改变;SHR各组血浆中6-Keto/TXB2比值均显著低于WKY组,不同年龄组SHR血浆中TXB2浓度相比,高年龄组明显高于低年龄组（2184.5±273.1比1290.6±284.4pg/ml,P<0.001）,高年龄组血浆中6-Keto-PGF1α浓度虽有升高,但6-Keto/TXB2比值仍明显低于对照组（0.21±0.12比1.48±0.78,P<0.001）。这些变化可能与SHR高血压的持续发展有关。

引用

页码：237 / 240

页数：4

共 8 条

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