血管内皮抑素联合放射的机制研究进展

被引：1

作者：

庄洪卿

秦培艳

袁智勇

机构：

[1] 天津医科大学附属肿瘤医院天津市肺癌诊疗中心天津市肿瘤防治重点实验室

来源：

中华放射肿瘤学杂志 | 2010年 / 03期

关键词：

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

<正> 新生血管形成是肿瘤生长和播散的必要条件,肿瘤血管也自然成为抗肿瘤治疗的天然靶区。在众多的抗血管生成药物中,血管内皮抑素以其较为突出的抗肿瘤作用,尤其令人瞩目。但血管内皮抑素(endostatin,ES)联合放射的研究相对较少,其确切机制亦不清楚,故作一综述。一、关于ES早在1971年,美国学者Folkman首先提出了肿瘤生长和转移依赖于血管形成的学说。根据该理论,1997年Folkman实验室的O’Reilly等发现并鉴定了ES,它是一种内源性血管形成抑制因子,能有效抑制机体内病理性血管形成,具有广谱抗肿瘤作用且无明显毒性反应。多年来,国内

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