粘附分子CD29和VEGF在胃癌组织中的表达及临床意义

被引：4

作者：

汪春福

邹桂华

江庆萍

杨惠娴

温寿青

机构：

[1] 深圳市宝安区人民医院

来源：

现代肿瘤医学 | 2008年 / 02期

关键词：

胃癌; 整合素; 粘附分子CD29; 血管内皮生长因子;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

目的:探讨胃癌组织中粘附分子CD29的表达水平及其与血管内皮生长因子(vascular endothelial grouth factor,VEGF)的关系。方法:选择胃癌患者84例和浅表性胃炎患者48例对CD29和VEGF抗体SP法免疫组化染色。结果:84例胃癌标本中CD29有68例阳性,阳性率为80.9%,48例浅表性胃炎组织中有12例阳性表达,阳性率为25%(P<0.05)。胃癌中70例(83.3%)VEGF阳性表达。其中有63例VEGF与CD29共同表达。具显著正相关(P<0.05)。CD29的表达与患者的年龄、性别和肿瘤的大小、组织学类型及浸润深度无关。但与肿瘤的淋巴结转移具有显著的相关性(P<0.05)。结论:CD29可通过介导VEGF的表达促进肿瘤新生血管的形成,从而进一步促进肿瘤的生长和转移。

引用

页码：226 / 228

页数：3

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