白细胞介素8在人乳腺癌细胞侵袭和增殖中的作用

被引:5
作者
林颖 [1 ]
王深明 [1 ]
吕伟明 [1 ]
黄若磐 [2 ]
机构
[1] 中山大学附属第一医院乳腺病诊治中心
[2] 美国亚特兰大EMORY大学
关键词
乳腺肿瘤; 白细胞介素8; 细胞因子; 蛋白质芯片;
D O I
暂无
中图分类号
R737.9 [乳腺肿瘤];
学科分类号
100214 ;
摘要
目的探讨白细胞介素8(IL-8)在乳腺癌细胞侵袭和增殖中的作用。方法运用细胞因子抗体芯片技术分析11株人类乳腺癌细胞的细胞因子表达谱,研究细胞因子在乳腺癌进展中的作用机制。结果细胞因子表达谱显示IL-8的表达水平与乳腺癌细胞雌激素受体状态,转移能力和波形丝蛋白的状态均相关,与人类乳腺癌细胞的侵袭直接正相关。IL-8抗体可以特异性地阻断IL-8介导的细胞侵袭作用,但对乳腺癌细胞增殖无明显作用。结论IL-8可能是乳腺癌进展和细胞侵袭中的关键因子,在乳腺癌细胞侵袭中起重要作用。
引用
收藏
页码:1541 / 1544
页数:4
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