IL-33在免疫相关疾病中的研究进展

被引：21

作者：

谢莉 ^{[1
,2
]}

朱平 ^{[1
,2
]}

机构：

[1] 三峡大学第一临床医学院

[2] 宜昌市中心人民医院肾病内科

来源：

免疫学杂志 | 2013年 / 29卷 / 06期

关键词：

IL-33; 蠕虫感染; 哮喘; 过敏性反应;

D O I：

10.13431/j.cnki.immunol.j.20130116

中图分类号：

R392.9 [其他医学免疫学];

学科分类号：

100102 ;

摘要：

IL-33,IL-1家族新成员,在前炎性因子刺激下表达在多种细胞而且被认为在细胞裂解时释放出来。IL-33的受体ST2和IL-1RAP也广泛表达在多种细胞特别是Th2和肥大细胞表面。IL-33能保护宿主抗蠕虫感染;能促进Th2反应而降低动脉粥样硬化的发生。相反,IL-33同样能加重由肥大细胞介导的哮喘、关节炎、遗传性过敏皮炎及过敏反应等。IL-33可能作为这些疾病的新的治疗靶点。

引用

页码：535 / 539

页数：5

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