丁基苯酞对大鼠局部脑缺血再灌注损伤皮层钙凋磷酸酶和钙蛋白酶活性的影响

被引：38

作者：

董高翔

冯亦璞

机构：

[1] 中国医学科学院、中国协和医科大学药物研究所!北京,中国医学科学院、中国协和医科大学药物研究所!北京

来源：

药学学报 | 2000年 / 10期

关键词：

丁基苯酞; 脑缺血; 神经细胞凋亡; 钙凋磷酸酶; 钙蛋白酶;

D O I：

10.16438/j.0513-4870.2000.10.017

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

AIM To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities. METHODS The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods. RESULTS DL -NBP and D -NBP 20 mg·kg -1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L -NBP 20 mg·kg -1 showed no obvious effect. CONCLUSION The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.

引用

页码：790 / 792

页数：3

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