颅脑外伤后认知功能障碍恢复的实验研究进展

被引:17
作者
罗爱华 [1 ,2 ]
窦祖林 [1 ]
机构
[1] 中山大学附属第三医院康复医学科
[2] 广州医学院第二附属医院康复医学科
关键词
D O I
暂无
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
100204 [神经病学];
摘要
<正>主要由交通意外引起的颅脑外伤(traumatic brain inju-ry,TBI)已成为工业化国家45岁以下人群的首要致死和致残原因。在美国,每年估计有140多万人遭遇颅脑外伤,有8—9万人遭受脑外伤后出现持久的功能障碍[1]。临床研究已表明,轻度颅脑外伤患者有10%—15%存在长期的认知和行为功能障碍,中度颅脑外伤患者至少有50%存在长期的损伤相
引用
收藏
页码:881 / 883
页数:3
相关论文
共 13 条
[1]
颅脑外伤后继发性脑损伤发病机制研究进展 [J].
贾林伟 ;
刘莉 ;
张更申 .
脑与神经疾病杂志, 2008, (03) :236-237+197
[2]
Statins in Traumatic Brain Injury [J].
Wible, Elissa F. ;
Laskowitz, Daniel T. .
NEUROTHERAPEUTICS, 2010, 7 (01) :62-73
[3]
PERSISTENT WORKING MEMORY DYSFUNCTION FOLLOWING TRAUMATIC BRAIN INJURY: EVIDENCE FOR A TIME-DEPENDENT MECHANISM [J].
Hoskison, M. M. ;
Moore, A. N. ;
Hu, B. ;
Orsi, S. ;
Koboric, N. ;
Dash, P. K. .
NEUROSCIENCE, 2009, 159 (02) :483-491
[4]
Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis [J].
Bales, James W. ;
Wagner, Amy K. ;
Kline, Anthony E. ;
Dixon, C. Edward .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2009, 33 (07) :981-1003
[5]
Time-dependent alterations of cholinergic markers after experimental traumatic brain injury.[J].Cornelius K. Donat;Martin U. Schuhmann;Cornelia Voigt;Karen Nieber;Winnie Deuther-Conrad;Peter Brust.Brain Research.2008,
[6]
Effects of the dopaminergic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: A study using positron emission tomography (PET) [J].
Kraus, MF ;
Smith, GS ;
Butters, M ;
Donnell, AJ ;
Dixon, E ;
Yilong, C ;
Marion, D .
BRAIN INJURY, 2005, 19 (07) :471-479
[7]
Gender and environmental effects on regional brain-derived neurotrophic factor expression after experimental traumatic brain injury.[J].X. Chen;Y. Li;A.E. Kline;C.E. Dixon;R.D. Zafonte;A.K. Wagner.Neuroscience.2005, 1
[8]
Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury [J].
Gaulke, LJ ;
Horner, PJ ;
Fink, AJ ;
McNamara, CL ;
Hicks, RR .
MOLECULAR BRAIN RESEARCH, 2005, 141 (02) :138-150
[9]
The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise [J].
Griesbach, GS ;
Gomez-Pinilla, F ;
Hovda, DA .
BRAIN RESEARCH, 2004, 1016 (02) :154-162
[10]
Recovery from brain injury in animals: relative efficacy of environmental enrichment; physical exercise or formal training (1990–2002).[J].Bruno Will;Rodrigue Galani;Christian Kelche;Mark R Rosenzweig.Progress in Neurobiology.2004, 3