TGF-β肾小球系膜增殖或抑制中的调节机制

被引：3

作者：

邹敏书

机构：

[1] 第二军医大学长征医院儿科!上海

来源：

国外医学(儿科学分册) | 2001年 / 03期

关键词：

转化生长因子β; 肾硬化症;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

转化生长因子β（ＴＧＦ－β）与组织细胞的发育形成、创伤修复、免疫调节、肿瘤发生、细胞黏附、凋亡等有关，其过度生成可导致多种器官纤维化。近年来，ＴＧＦ－β在肾脏病中的功能作用报道颇多，在导致细胞外基质聚积，进而肾小球硬化上起着中心调节作用。因此，探讨ＴＧＦ－β对系膜的调控机制具有重要意义。本文对ＴＧＦ－β在肾小球系膜增殖或抑制中的调节机制和影响因素作一综述。

引用

页码：137 / 141

页数：5

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