同型半胱氨酸与冠状动脉病变的相关性

被引：14

作者：

王战坤

郑良荣

王兴祥

陈君柱

机构：

[1] 浙江大学医学院附属第一医院内科

来源：

中华急诊医学杂志 | 2003年 / 11期

关键词：

同型半胱氨酸; 冠心病; 内皮; 叶酸VitB12;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

摘要：

目的　探讨同型半胱氨酸 (Hcy)与冠状动脉病变的相关性及其致病机制。方法　测定 98冠心病患者和 6 7例对照组血浆Hcy、VitB1 2 、叶酸、内皮素和血清NO。计算冠心病患者的冠脉病变的Gensini积分。结果　 (1)血浆Hcy与VitB1 2 、叶酸均呈负相关 (r=- 0 4 0 7,r =- 0 338,P <0 0 1) ;(2 )冠心病组患者血浆Hcy高于对照组 [(14 12± 4 78) μmol/L ,和 (9 6 2± 2 4 5 ) μmol/L ,P<0 0 1],Hcy与冠脉病变程度呈正相关 (r=0 4 11,P <0 0 1) ,多元回归分析显示Hcy对冠心病的相对危险度 1 2 8(95 %可信区间1 12～ 1 4 7,P <0 0 1) ;(2 )Hcy分别与内皮素和NO呈正相关和负相关 (r=0 4 2 2 ,r=- 0 36 5 ,respective ly,bothP <0 0 1) ,高Hcy患者血管内皮依赖性舒张功能明显受损 [(8 86± 4 33) %和 (15 72± 5 2 8) % ,P<0 0 1]。结论　VitB1 2 和叶酸缺乏可引起Hcy蓄积 ,高Hcy可能损伤血管内皮 ,是冠心病的危险因素。

引用

页码：752 / 754

页数：3

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