靶向β和γ分泌酶治疗阿尔茨海默病的研究进展

被引:4
作者
肖飞
罗焕敏
机构
[1] 暨南大学药学院药理学教研室,暨南大学药学院药理学教研室广东广州,广东广州
关键词
阿尔茨海默病; β淀粉样蛋白; 分泌酶; 药物治疗;
D O I
10.13220/j.cnki.jipr.2002.05.006
中图分类号
R749.16 [];
学科分类号
100203 ;
摘要
β淀粉样蛋白沉积所形成的老年斑是阿尔茨海默病 (AD)的三大病理改变之一。淀粉样蛋白代谢关键的分泌酶成为治疗AD很有潜力的靶点 ,β和γ分泌酶及其抑制剂成为AD的研究热点。本文介绍了近年来在 β淀粉样蛋白假说、分泌酶及其抑制剂上所取得的研究进展和尚存在的不足 ,为此类新药的开发提供一个很好的参考依据。
引用
收藏
页码:272 / 278
页数:7
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