氨肽酶N及其抑制剂与肿瘤

被引:6
作者
裴可灵
张厚莉
崔淑香
机构
[1] 山东省医学科学院药物研究所山东省罕少见病重点实验室
关键词
抗原,CD13; 肿瘤侵润; 肿瘤转移;
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 ;
摘要
氨肽酶N(APN)是一种锌离子依赖性的外肽酶,在多种肿瘤细胞表面高表达,可降解细胞外基质,促进血管生成,从而促进肿瘤侵袭转移。氨肽酶N抑制剂可抑制肿瘤侵袭转移,诱导肿瘤细胞凋亡,已成为抗肿瘤治疗的一个有吸引力的靶点。
引用
收藏
页码:169 / 171 +233
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