基质金属蛋白酶9及其在心血管疾病中的研究进展

被引：11

作者：

唐利娜 ^{[1
]}

吴旻 ^{[2
]}

机构：

[1] 汕头大学医学院

[2] 汕头大学医学院第一附属医院心内科

来源：

医学综述 | 2011年 / 17卷 / 06期

基金：

广东省自然科学基金;

关键词：

基质金属蛋白酶9; 心血管疾病; 药物治疗;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

1002 ; 100201 ;

摘要：

基质金属蛋白酶9(MMP-9)又称明胶酶B,是基质金属蛋白家族中的一个重要成员,能够降解Ⅳ型胶原等多种细胞外基质成分。MMP-9在生理情况下参与人体的正常发育,病理状态下潜在型MMP-9被激活,通过削减斑块纤维帽参与心室重构。在多种心血管疾病的发生、发展中起重要作用,并且有望成为反映心血管疾病的一种生物标志物,而对MMP-9的调节将是一个可能的治疗靶点。现就MMP-9的基因、蛋白、活性调节、信号转导及其在心血管疾病中的研究进展予以综述。

引用

页码：801 / 804

页数：4

共 11 条

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