锌与维生素D缺乏对大鼠骨钙化及发育的影响

被引:3
作者
徐波
郑德元
钱幼琼
吴康敏
机构
[1] 华西医大附属第二医院儿科,华西医大附属第二医院儿科,华西医大附属第二医院儿科,华西医大附属第二医院儿科
关键词
锌缺乏; 骨钙化; 动物模型; 骨发育;
D O I
暂无
中图分类号
学科分类号
摘要
作者通过喂养缺锌饲料建立了缺锌动物模型,发现大鼠缺锌后出现骨钙降低,骨X线摄片显示骨皮质变薄、骨密度降低,同时光镜下可见长骨骺端软骨细胞及肥大细胞减少,肥大细胞变小.由此提示缺锌同样能引起骨钙化障碍,且与维生索D缺乏时的骨钙化障碍表现相似,同时还可能引起软骨内成骨受损,阻碍长骨的增长。作者认为这可能是缺锌所致侏儒的原因。而及时补锌,缺锌造成的骨损害可以治愈.
引用
收藏
页码:288 / 292
页数:5
相关论文
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