血D-二聚体检测在类风湿关节炎中的临床意义

被引:20
作者
赵金霞
孙琳
张霞
刘湘源
机构
[1] 北京大学第三医院风湿免疫科
关键词
关节炎,类风湿; 生物医学研究; D-二聚体;
D O I
暂无
中图分类号
R593.22 [类风湿性关节炎];
学科分类号
100201 [内科学];
摘要
目的检测类风湿关节炎(RA)患者血中D-二聚体水平,探讨其在RA中的临床意义。方法本研究纳入RA患者58例,疾病对照组患者64例(包括系统性红斑狼疮18例、血清阴性脊柱关节病15例、骨关节炎11例、其他结缔组织病20例)。所有患者均排除血栓性疾病,近6个月无手术、外伤和肿瘤病史。记录患者的临床和实验室指标,采用免疫比浊法检测血中D-二聚体水平。并研究其与RA患者疾病活动度(DAS28评分)、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)等指标的关系。采用Mann-Whitney U检验、t检验及Spearman相关分析。结果①RA患者血D-二聚体增高的比例明显高于疾病对照组(分别为82.6%和21.9%,P<0.01)。血D-二聚体水平在RA患者中明显高于对照组[分别为(1.76±1.57)和(0.32±0.25)mg/L,P<0.01]。②在RA患者中,D-二聚体增高组DAS28水平高于D-二聚体正常组(5.4±1.0和4.4±0.8,P 更多 还原 AbstractFilter('ChDivSummary', 'ChDivSummaryMore', 'ChDivSummaryReset');
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