CH25H与阿尔茨海默病

被引:4
作者
王璐璐
张孟仁
机构
[1] 中国医学科学院/北京协和医学院北京协和医院中医科
关键词
CH25H; 25HC; 阿尔茨海默病; 认知功能障碍;
D O I
暂无
中图分类号
R749.16 [];
学科分类号
摘要
胆固醇25-羟基氢化酶(cholesterol 25-hydroxylase,CH25H)基因位于染色体10q23,编码CH25H,参与合成25羟基胆固醇(25-hydroxycholesterol,25HC),是与阿尔茨海默病发病密切相关的基因之一。研究表明,25HC可刺激s PLA2-ⅡA的分泌、诱导caspase-3的表达等以引起少突胶质细胞凋亡,可以通过增加大脑内β-淀粉样蛋白负荷、调节胆固醇脂代谢、提高载脂蛋白E的表达等,影响认知功能障碍。
引用
收藏
页码:173 / 175
页数:3
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