联合应用神经保护剂抑制大鼠局灶性脑缺血后的神经元凋亡

被引：4

作者：

李志梅 ^{[1
]}

丁成赟 ^{[1
]}

王维平 ^{[2
]}

王晓鹏 ^{[2
]}

机构：

[1] 首都医科大学天坛医院神经内科

[2] 河北医科大学第二医院神经内科

来源：

基础医学与临床 | 2006年 / 12期

关键词：

脑缺血; 神经保护剂; 联合; 凋亡; caspase-3;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨联合应用神经保护剂能否较单一用药更好地达到保护脑的作用。方法采用线栓法制作大鼠大脑中动脉闭塞模型(MCAO),分为对照组、1,6-二磷酸果糖(FDP)组、MK-801组、N-乙酰半胱氨酸(NAC)组、联合治疗组和假手术组。应用TUNEL染色检测神经元凋亡,免疫组化及W estern b lot检测caspase-3蛋白表达。结果缺血后6 h和24 h,联合治疗组神经元凋亡和caspase-3蛋白表达均明显少于各单一用药组(P<0.05)。结论联合应用神经保护剂对大鼠局灶性脑缺血的保护作用明显增强。

引用

页码：1359 / 1362

页数：4

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