血清瓜氨酸、a谷胱甘肽s转移酶在危重症病人肠屏障功能障碍中的研究进展

被引：3

作者：

李敏锐

徐鹏远

机构：

[1] 昆明医科大学第二附属医院

来源：

世界最新医学信息文摘 | 2018年 / 18卷 / 18期

关键词：

危重症患者; 肠屏障功能障碍; 瓜氨酸; α-谷胱甘肽s转移酶;

D O I：

10.19613/j.cnki.1671-3141.2018.18.036

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

危重症病人一般是指患有威胁生命的高风险病人,即便积极治疗也可能恢复困难。这类病人通常合并血流动力学障碍、肠道缺血-再灌注、肠屏障破坏、菌群移位等问题,导致胃肠动力及分泌功能紊乱,营养摄入缺乏,免疫细胞凋亡,通透性增加,甚至促发全身炎症反应,多器官功能衰竭,甚至死亡。由此有效评估肠道功能及肠功能障碍严重程度成为当前热点。瓜氨酸大都在肠道黏膜上皮细胞合成,通过检测血清瓜氨酸浓度可以评估肠道肠黏膜上皮细胞的数量和功能。而谷胱甘肽S转移酶(GST)是一种胞质酶的家族,在肠道内广泛分布,当细胞膜被破坏时,它参与排毒并从多种细胞中释放出来。因此,监测血清瓜氨酸及谷胱甘肽S转移酶(GST)浓度可以评估危重症患者的肠道功能及其严重程度。

引用

页码：82 / 84+92 +92

页数：4

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