3,4′,5-三羟基芪-3-β-单-D-葡萄糖苷减轻动脉内皮损伤性血栓形成的作用(英文)

被引：15

作者：

王跃忠

骆苏芳

张佩文

余传林

机构：

[1] 第一军医大学药理教研室

[2] 第一军医大学药理教研室广州中国

[3] 广州中国

[4] 广州

来源：

Acta Pharmacologica Sinica | 1995年 / 02期

关键词：

3,4′,5-三羟基芪-3-β-单-D-葡萄糖苷; 血管内皮; 血栓; 培养的细胞; 血小板聚集; 血栓素A2; 依前列醇; 虎杖苷;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的:3,4′,5-三羟基芪-3-β-单-D-葡萄糖苷（Polydatin,Pol）对兔颈动脉内皮损伤性血栓形成的影响.方法:采用胰蛋白酶损伤兔颈动脉内皮诱导血栓形成模型.结果:Pol iv 5或10 mg·kg-1均可显著减少血栓湿重（P<0.05,P<0.01）并抑制血小板聚集（P<0.05,P<0.01）.Pol 0.30—1.15 mmol·L-1抑制血小板TXA2生成（P<0.05,P<0.01）,不影响人脐静脉内皮细胞生成PGI2.结论:Pol具有抗血栓作用;不减少PGI2,选择性抑制TXA2是其重要机制之一.

引用

页码：65 / 68

页数：4

共 8 条

[1]

Effects of polydatin on platelet aggregation of rabbits. Shan CW. Acta Pharmacological Sinica . 1988

[2]

Culture of endothelial cells derived from human umbilical cord vein and rat aorta. Zhang BG,Chen TZ,Zhang JF,Dong YL,Wang TJ,Liu KL. Chinese Journal of Cardiology . 1985

[3]

Culture of human endothelial cells derived from umbilical veins.Identification by morphologic and immunologic criteria. Jaffe EA,Nachman RL,Becker CG,Minick CR. The Journal of Clinical Investigation . 1973

[4]

The role of thromboxane （TX） A2 in rabbit arterial thrombosis induced by endothelial damage. Imura Y,Terashita Z,Nishikawa K. Thrombosis Research . 1990

[5]

Aggregation of blood platelet by adenosine diphosphate and its reversal. Born GYR. Nature . 1962

[6]

Radioimmunoassay of 125 I-labeled 6-keto-prostaglandin F1（?）. Chen DC,Wan ZY,He Y,Ruan CG. Chinese Journal of Nuclear Medicine . 1986

[7]

Influence of 3, 4’, 5-trihydroxystibene-3-β-mono-D-glucoside on rabbits’ platelet aggregation and thromboxane B2 production in vitro. Shan CW,Yang SQ,He HD,Shao SL,Zhang PW. Acta Pharmacological Sinica . 1990

[8]

A simple and efficient method for platelet isolation from their plasma. Lagarde M,Bryon PA,Guichardant M,Dechavanne M. Thrombosis Research . 1980

← 1 →