音猬因子信号通路与骨质疏松症关系的研究进展

被引：10

作者：

许周媚 ^{[1
]}

王清辉 ^{[1
]}

查旋 ^{[1
]}

徐道华 ^{[1
,2
]}

机构：

[1] 广东医科大学药理学教研室

[2] 广东医科大学中药与新药研究所

来源：

中国骨质疏松杂志 | 2017年 / 23卷 / 04期

基金：

广东省自然科学基金; 广东省科技计划;

关键词：

Sonic Hedgehog信号通道; 骨质疏松; 成骨分化; 成脂分化;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨发育的过程受到多种信号通路的调节,如Wnt、Notch、BMP、Hedgehog信号通路等。Hedgehog信号通路对骨形成的作用在过去的二十几年已经被证实。音猬因子(Ssonic hedgehog,Shh)在Hedgehog家族中表达最广泛,在该信号传导通路上对轴骨、四肢骨、颅面骨等骨骼的形成起着重要作用。骨质疏松症发病机制归根到底是成骨细胞的骨形成能力与破骨细胞的骨吸收之间的平衡被打破,并且成骨细胞的骨形成作用下降是其主要影响因素之一。本文主要从分子水平对Shh信号通路与影响骨质疏松症发生的几个主要因素进行综述,为Shh信号通路应用于骨质疏松的防治提供理论依据。

引用

页码：534 / 540+547 +547

页数：8

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