心肌缺血-再灌注损伤钙超载及其防治策略

被引：22

作者：

罗涛

岳荣川

胡厚祥

机构：

[1] 川北医学院第一附属医院心血管内科

来源：

国际心血管病杂志 | 2011年 / 38卷 / 01期

关键词：

缺血-再灌注损伤; 心肌; 钙超载; 线粒体膜通透性转换孔; 肌(内)质网钙泵;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

缺血-再灌注(I-R)可引起肌膜损伤、Na+/Ca2+交换逆转以及肌(内)质网钙泵(SERCA)含量或活性下降从而导致心肌钙超载。钙超载诱导心肌Calpain活化与线粒体膜通透性转换孔(mPTP)开放进而引起心肌细胞收缩功能障碍、凋亡甚至坏死。通过抑制Na+/Ca2+交换蛋白、Na+/H+交换蛋白、Calpain活性、mPTP开放、Ryanodine受体及IP3受体,或提高SERCA2a含量或活性均能显著减轻I-R心肌钙超载;采用酸性再灌注、缺血后适应与缺血预适应等措施也被证实能有效防治I-R损伤。进一步研究探索防治心肌I-R损伤策略对于缺血性心脏病的防治具有深远的意义。

引用

页码：21 / 23+40 +40

页数：4

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