脂肪源性干细胞的定向分化潜能及临床应用前景

被引：12

作者：

王伟 ^{[1
,2
]}

撒亚莲 ^{[1
,2
]}

严新民 ^{[1
,2
]}

机构：

[1] 云南省第一人民医院

[2] 昆明医学院附属昆华医院临床基础医学研究所

来源：

中华临床医师杂志(电子版) | 2011年 / 5卷 / 02期

关键词：

D O I：

暂无

中图分类号：

R329 [人体组织学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

<正>脂肪源性干细胞(adipose-derived stem cells,ADSCs)是一种具有自我更新与多向分化潜能的成体间充质干细胞。在特定诱导条件下,ADSCs具有跨越胚层分化的潜能。本文就ADSCs的定向分化潜能及其作为细胞治疗与组织工程的种子细胞、基因治疗载体的临床应用前景进行综述。一、ADSCs的生物学特性ADSCs是由Zuk等[1]于2001年首次从人吸脂术的脂肪悬液中得到的一种间充质干细胞。

引用

页码：461 / 464

页数：4

共 13 条

[1]

人脂肪源性间充质干细胞向内耳毛细胞定向诱导分化的实验研究 [J].

袁先道 ;

闫曦 ;

杨华 ;

高志强 ;

李康华 ;

韩钦 ;

卢姗 ;

陈晓巍 ;

姜鸿 ;

赵春华 .

中华耳鼻咽喉头颈外科杂志, 2009, (04)

[2]

In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model..E. Yoon;S. Dhar;D.E. Chun;N.A. Gharibjanian;G.R. Evans;.Tissue Eng.2007, 03

[3]

Pre-adipocytes commitment to neurogenesis 1: Preliminary localisation of cholinergic molecules [J].

Aluigi, Maria Grazia ;

Coradeghini, Rosella ;

Guida, Chiara ;

Scanarotti, Chiara ;

Bassi, Anna Maria ;

Falugi, Carla ;

Santi, PierLuigi ;

Raposio, Edoardo .

CELL BIOLOGY INTERNATIONAL, 2009, 33 (05) :594-601

[4]

MicroRNA regulation of neuron-like differentiation of adipose tissue- derived stem cells [J].

Ning, Hongxiu ;

Huang, Yun-Ching ;

Banie, Lia ;

Hung, Steven ;

Lin, Guiting ;

Li, Long-Cheng ;

Lue, Tom F. ;

Lin, Ching-Shwun .

DIFFERENTIATION, 2009, 78 (05) :253-259

[5]

Potential of Adipose‐Derived Stem Cells for Treatment of Erectile Dysfunction.[J].Guiting Lin;Lia Banie;Hongxiu Ning;Anthony J. Bella;Ching‐Shwun Lin;Tom F. Lue.The Journal of Sexual Medicine.2009, S3

[6]

Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice [J].

Kucerova, Lucia ;

Matuskova, Miroslava ;

Pastorakova, Andrea ;

Tyciakova, Silvia ;

Jakubikova, Jana ;

Bohovic, Roman ;

Altanerova, Veronika ;

Altaner, Cestmir .

JOURNAL OF GENE MEDICINE, 2008, 10 (10) :1071-1082

[7]

Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells [J].

Aksu, A. Emre ;

Rubin, J. Peter ;

Dudas, Jason R. ;

Marra, Kacey G. .

ANNALS OF PLASTIC SURGERY, 2008, 60 (03) :306-322

[8]

Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model.[J].Jeong-Min Kim;Soon-Tae Lee;Kon Chu;Keun-Hwa Jung;Eun-Cheol Song;Se-Jeong Kim;Dong-In Sinn;Jin-Hee Kim;Dong-Kyu Park;Kyung-Mook Kang;Nan Hyung Hong;Hee-Kwon Park;Chong-Hyun Won;Kyu-Han Kim;Manho Kim;Sang Kun Lee;Jae-Kyu Roh.Brain Research.2007,

[9]

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells [J].