氧化型低密度脂蛋白胆固醇与动脉粥样硬化

被引：23

作者：

徐瑞霞

李建军

机构：

[1] 中国医学科学院阜外心血管病医院血脂异常与心血管疾病诊疗中心

来源：

中国医学前沿杂志(电子版) | 2012年 / 08期

基金：

北京市自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

100201 [内科学];

摘要：

<正>动脉粥样硬化(atherosclerosis,AS)的形成过程极其复杂,其发病机制涉及炎性反应、脂质代谢失调及氧化应激等多种病理生理机制[1-3]。其中,低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)的氧化修饰被认为是AS形成的关键启动因素[4]。研究表明,氧化低密度脂蛋白(oxidized low density lipoprotein,oxLDL)的细胞毒性作用可引起血管内皮细胞功能和结构的

引用

页码：33 / 37

页数：5

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