肥胖高血压患者血清抵抗素水平与代谢紊乱的临床研究

被引：7

作者：

董平栓

王绍欣

李志鹃

王红雷

范喜梅

尚喜艳

闫鹏

杨旭明

杨喜山

机构：

[1] 河南科技大学第一附属医院心内科

来源：

医药论坛杂志 | 2008年 / 14期

关键词：

肥胖高血压; 抵抗素; 胰岛素抵抗; 代谢紊乱;

D O I：

暂无

中图分类号：

R589.2 [脂肪代谢障碍]; R544.1 [高血压];

学科分类号：

100201 [内科学];

摘要：

目的探讨肥胖高血压病患者血清抵抗素(resistin)水平的临床意义及其与血脂、血压、体重指数(BMI)、腰臀比(WHR)、胰岛素敏感指数(ISI)等代谢紊乱的关系。方法测定40例肥胖高血压患者及40例正常人血清抵抗素、人体测量变量值及生化指标。结果肥胖高血压组血清抵抗素显著高于对照组;血清抵抗素水平与BMI(r=-0.628,P<0.01)、WHR(r=-0.545,P<0.01)、TG(r=-0.724,P<0.01)、LDL(r=-0.321,P<0.05)胰岛素(INS)(r=0.521,P<0.01)正相关,与ISI(r=0.569,P<0.01)、HDL(r=0.483,P<0.01)负相关,与TC(r=-0.222,p>0.05)无相关性。结论肥胖高血压患者常伴有血清抵抗素增高与代谢紊乱;血清抵抗素水平与肥胖高血压发病及代谢紊乱相关联。

引用

页码：84 / 86

页数：3

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