气相色谱质谱法测定肝、肾和肉中11种β-受体激动剂残留量

被引：66

作者：

朱坚

李波

方晓明

陈家华

杨景贤

机构：

[1] 上海出入境检验检疫局

来源：

质谱学报 | 2005年 / 03期

关键词：

β-受体激动剂; 残留量; 气相色谱质谱法; 肝; 肾; 肉;

D O I：

暂无

中图分类号：

O657.73 [];

学科分类号：

摘要：

对用气相色谱质谱法(GC/MS)同时测定肝、肾和肉中11种β受体激动剂残留的方法进行研究。样品经pH5.2的乙酸钠缓冲溶液提取,提取液经β盐酸葡萄糖醛苷酶芳基硫酸酯酶水解,用高氯酸沉淀蛋白质,经异丙醇乙酸乙酯(6∶4,体积比)液液分配,再经阳离子交换树酯(SCX)小柱净化后,用N,O双(三甲基硅基)三氟乙酰胺衍生化。用美托洛尔为内标,同时测定11种β受体激动剂。对肝、肾和肉样品进行添加回收实验,平均回收率为71%～94%,变异系数为4.6%～18.7%,最低检测限(LOQ)为0.002～0.000mg/kg。

引用

页码：129 / 137

页数：9

共 18 条

[1]

Determination of Fenoterol and Rectopamine in Urine by Enzyme Immunoassay. Haasnoot W,Stouten P,Lommen A. The Analyst . 1994

[2]

BrambillaG,CivitarealeC,PierdominiciE,etal. The Analyst . 1994

[3]

β2AgonisticDrugs inUrineofMeat producingAnimalsbyGas Chromatography MassSpectrometry. M PMontrade,BLeBizec. Analytica Chimica Acta . 1993

[4]

HyphenationofCoupled columnLiquidChro matographyandThermosprayTandemMass SpectrometryfortheRapidDeterminationofβAgonistResiduesinBovineUrineUsingDirect Large volumeSampleInjection. HogendoornEA,vanZoonenP,PolettiniA,et al. JMassSpec trom . 1996

[5]

Multi residue AnalysisforβAgonistsinUrineandLiverSam plesUsingMixedPhaseColumnswithDetermi nationbyRadioimmunoassay. CollinsS,O‘eeffeM,SmythMR. The Analyst . 1994

[6]

ResidueScreen ingfortheβAgonistsClenbutrol,Salbutamol andCimaterolinUrineUsingEnzymeImmunoas sayandHigh performanceLiquidChromatogra phy. MeyerHH,RinkeL,DurschI. Journal of Chromatography . 1991

[7]

Gas andLiquidChromatographyCoupledtoTandemMassSpectrometryforMultiresidueAnalysisofβAgonistsinBiologicalMatrices. VanVynchtG,,PreeceS,GasparP,etal. JChromatogr A . 1996

[8]

RapidAnalysisofβAgonistsinUrinebyTher mosprayTandemMassSpectrometry. VanRhijnJA,O‘KeeffeM,HeskampHH,etal. JChro matogr.A . 1995

[9]

DeterminationofβSympathomimeticsinLiverand UrinebyImmunoaffinityChromatographyandGas Chromatography Mass SelectiveDetection. HooijerinkH,SchiltR,vanBennekomEO,etal. JChromatogrBBiomedAppl . 1994

[10]

βAgonistsin BovineLiverTissue. BoydD,O‘KeeffeM,SmythMR. The Analyst . 1994

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