两种不同来源的树突状细胞体外诱导CTL杀瘤作用的研究

被引:1
作者
何海新
叶韵斌
张其忠
周智锋
机构
[1] 福建省肿瘤医院
[2] 福建省肿瘤医院 福州
[3] 福州
关键词
树突状细胞; 外周血单个核细胞; 脐血; 杀伤性T淋巴细胞;
D O I
暂无
中图分类号
R73-36 [治疗实验];
学科分类号
100214 ;
摘要
目的比较两种不同来源的树突状细胞体外负载肿瘤抗原后激活CTL的杀瘤效果,探讨其在抗肿瘤免疫中的作用。方法分别应用相应的细胞因子组合建立外周血单个核细胞来源和脐血来源DC的培养体系。体外比较两类DC负载K562白血病细胞冻融抗原后激活CTL的杀瘤效果。结果在合适的细胞因子组合下,两种方法都能得到成熟的DC,两种来源的DC在负载了肿瘤抗原后对于CTL肿瘤的杀伤有明显的增效作用。结论外周血和脐血来源的DC功能相似,均可在肿瘤免疫中发挥重要作用。
引用
收藏
页码:386 / 390
页数:5
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