Rho激酶抑制剂的研究现状及其在神经系统疾病中的应用前景

被引：11

作者：

肖保国

机构：

[1] 复旦大学附属华山医院神经病学研究所

来源：

重庆医科大学学报 | 2008年 / S1期

关键词：

酶抑制剂; Rho; 神经系统疾病; 研究现状; 应用前景;

D O I：

10.13406/j.cnki.cyxb.2008.s1.025

中图分类号：

R741.05 [神经病治疗学];

学科分类号：

1002 ;

摘要：

<正>1R ho-R ho激酶系统及其抑制剂的研究现状Rho激酶(Rho kinases,ROCKs)是丝氨酸/苏氨酸蛋白激酶(Ser/Tkr蛋白激酶),分子量约为160ku[1]。可分为2个亚型:ROCK-Ⅰ(又称ROK!)和ROCK-Ⅱ(又称ROCK")[2]。

引用

页码：99 / 100+112 +112

页数：3

共 6 条

[1]

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis[J] . Xiaojia Sun,Motozumi Minohara,Hitoshi Kikuchi,Takaaki Ishizu,Masahito Tanaka,Hua Piao,Manabu Osoegawa,Yasumasa Ohyagi,Hiroaki Shimokawa,Jun-ichi Kira.Journal of Neuroimmunology . 2006 (1)

[2]

Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo[J] . Inflammation Research . 2006 (9)

[3]

Rho-Kinase Inhibition in the Therapy of Cardiovascular Disease[J] . Andrew Lai,William H. Frishman.Cardiology in Review . 2005 (6)

[4] Distribution of rho-kinase in the bovine brain [J].

Hashimoto, R ;

Nakamura, Y ;

Kosako, H ;

Amano, M ;

Kaibuchi, K ;

Inagaki, M ;

Takeda, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 263 (02) :575-579

[5]

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice[J] . Osamu Nakagawa,Kazuko Fujisawa,Toshimasa Ishizaki,Yuji Saito,Kazuwa Nakao,Shuh Narumiya.FEBS Letters . 1996 (2)

[6]

Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho[J] . T. Matsui,M. Amano,T. Yamamoto,K. Chihara,M. Nakafuku,M. Ito,T. Nakano,K. Okawa,A. Iwamatsu,K. Kaibuchi.The EMBO Journal . 1996 (9)

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