原发性胆汁性胆管炎的研究进展

被引:6
作者
段维佳
田秋菊
尤红
贾继东
机构
[1] 首都医科大学附属北京友谊医院肝病中心
关键词
肝硬化,胆汁性; 诊断; 治疗;
D O I
暂无
中图分类号
R575.7 [胆管疾病];
学科分类号
100201 [内科学];
摘要
原发性胆汁性胆管炎是一种慢性肝内胆汁淤积性疾病,文献报道其发病率和患病率不断提高。通过检查血清抗线粒体抗体M2亚型等特异性抗体或肝组织病理学检查可确定诊断。熊去氧胆酸是治疗本病的主要药物,但对熊去氧胆酸生化学应答欠佳者疾病进展快,目前尚无统一有效的治疗手段。加用布地奈德、非诺贝特、苯扎贝特或奥贝胆酸可能对部分患者有效,但仍需进一步临床研究验证。
引用
收藏
页码:2062 / 2065
页数:4
相关论文
共 14 条
[1]
原发性胆汁性肝硬化(又名原发性胆汁性胆管炎)诊断和治疗共识(2015) [J].
陈成伟 ;
成军 ;
窦晓光 ;
段维佳 ;
段钟平 ;
范建高 ;
傅青春 ;
高春芳 ;
侯金森 ;
胡和平 ;
胡锡琪 ;
黄建荣 ;
韩涛 ;
韩英 ;
贾继东 ;
陆伦根 ;
刘玉兰 ;
马雄 ;
茅益民 ;
南月敏 ;
牛俊奇 ;
邱德凯 ;
任红 ;
尚佳 ;
唐红 ;
王贵强 ;
王吉耀 ;
王建设 ;
王磊 ;
王宇明 ;
魏来 ;
许建明 ;
徐铭益 ;
谢青 ;
谢渭芬 ;
徐小元 ;
杨长青 ;
杨云生 ;
尤红 ;
曾民德 ;
张文宏 ;
张跃新 ;
周新民 ;
庄辉 ;
邹晓平 .
临床肝胆病杂志, 2015, (12) :1980-1988
[2]
抗M2型线粒体抗体筛查11024例结果分析 [J].
何宇晴 ;
刘强 ;
叶震璇 ;
李红梅 ;
杨必伟 ;
张华 .
中国现代医药杂志, 2015, 17 (11) :1-3
[3]
Characterization of M2 antibodies in asymptomatic Chinese population[J] Xiao-Hua Jiang Jian-Wen Sun Department of Laboratory Medicine;85 Hospital of Chinese PLA;Shanghai 200052;China Ren-Qian Zhong Xian-Tao Kong Clinical Immunology Center of PLA;Changzheng Hospital;Second Military Medical University;Shanghai 200003;China Xiao-Yun Fan Center of Liver Research;Nanjing Military Command;Shanghai 200052;China Yin Hu Shanghai University of Engineering Science;Shanghai 200335;China Feng An Department o
[4]
The UK‐PBC risk scores: Derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis[J] Marco Carbone;Stephen J. Sharp;Steve Flack;Dimitrios Paximadas;Kelly Spiess;Carolyn Adgey;Laura Griffiths;Reyna Lim;Paul Trembling;Kate Williamson;Nick J. Wareham;Mark Aldersley;Andrew Bathgate;Andrew K. Burroughs;Michael A. Heneghan;James M. Neuberger;Douglas Thorburn;Gideon M. Hirschfield;Heather J. Cordell;Graeme J. Alexander;David E.J. Jo
[5]
Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy[J] Willem J. Lammers;Gideon M. Hirschfield;Christophe Corpechot;Frederik Nevens;Keith D. Lindor;Harry L.A. Janssen;Annarosa Floreani;Cyriel Y. Ponsioen;Marlyn J. Mayo;Pietro Invernizzi;Pier M. Battezzati;Albert Parés;Andrew K. Burroughs;Andrew L. Mason;Kris V. Kowdley;Teru Kumagi;Maren H. Harms;Palak J. Trivedi;Raoul Poupon;Angela Cheung;Ana Lleo;Ll
[6]
Primary biliary cirrhosis[J] Elizabeth J Carey;Ahmad H Ali;Keith D Lindor The Lancet 2015,
[7]
Primary biliary cirrhosis: proposal for a new simple histological scoring system[J] Dominique Wendum;Pierre‐Yves Bo?lle;Pierre Bedossa;Elie‐Serge Zafrani;Frédéric Charlotte;Marie‐Christine Saint‐Paul;Sophie Michalak;Olivier Chazouillères;Christophe Corpechot Liver Int 2015,
[8]
Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid[J] Gideon M. Hirschfield;Andrew Mason;Velimir Luketic;Keith Lindor;Stuart C. Gordon;Marlyn Mayo;Kris V. Kowdley;Catherine Vincent;Henry C. Bodhenheimer;Albert Parés;Michael Trauner;Hanns-Ulrich Marschall;Luciano Adorini;Cathi Sciacca;Tessa Beecher-Jones;Erin Castelloe;Olaf Böhm;David Shapiro Gastroenterology 2015,
[9]
Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population[J] Minoru Nakamura;Nao Nishida;Minae Kawashima;Yoshihiro Aiba;Atsushi Tanaka;Michio Yasunami;Hitomi Nakamura;Atsumasai Komori;Makoto Nakamuta;Mikio Zeniya;Etsuko Hashimoto;Hiromasa Ohira;Kazuhide Yamamoto;Morikazu Onji;Shuichi Kaneko;Masao Honda;Satoshi Yamagiwa;Kazuhiko Nakao;Takafumi Ichida;Hajime Takikawa;Masataka Seike;Takeji Umemura;Yoshiyuki Ueno;Shot
[10]
Liver transplantation in PBC and PSC: Indications and disease recurrence[J] Marco Carbone;James Neuberger Clinics and Research in Hepatology and Gastroenterology 2011,