磷酸化Akt蛋白表达在非小细胞肺癌中的临床意义

被引：9

作者：

汤建民

何权瀛

常秀军

机构：

[1] 北京大学人民医院呼吸科

[2] 北京结核病和胸部肿瘤研究所北京

[3] 北京

来源：

中国呼吸与危重监护杂志 | 2005年 / 03期

关键词：

Akt; 非小细胞肺癌; 免疫组织化学染色; 预后;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100214 ;

摘要：

目的　探讨磷酸化Akt(p Akt)蛋白表达与非小细胞肺癌(NSCLC)患者临床病理参数及预后的关系。方法　应用免疫组织化学SP法检测2 0例正常肺组织和10 2例NSCLC患者癌组织中p Akt蛋白的表达,NSCLC患者随访时间为3～6 0个月。结果　NSCLC癌组织中p Akt蛋白表达的阳性率为4 1 2 % (42 / 10 2 ) ,而正常肺组织为阴性。p Akt蛋白阳性与肿瘤组织分化程度、临床分期以及有无淋巴结和远处转移相关。p Akt蛋白阳性表达者5年生存率和中位生存时间显著低于阴性者(分别为14 2 9%和33 33% ;14个月和32个月,Logrank检验χ2 =14 2 4 ,P =0 0 0 0 2 )。结论p Akt蛋白表达与NSCLC发展有关,是预测NSCLC患者不良预后的独立危险因素

引用

页码：193 / 197+245 +245

页数：6

共 10 条

[1]

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Brognard J,Clark AS,Ni Y,et al. Cancer Research . 2001

[2]

Altered portein kinase C(PKC) isoforms in non-small cell lung cancer cells: PKC delta promotes cellular survival and chemotherapeutic resistance. Clark AS,West KA,Blumberg PM,et al. Cancer Research . 2003

[3]

Deletion of tumor suppressor genes in Chinese non-small cell lung cancer. An Q,Liu Y,Gao Y,et al. Cancer Letters . 2002

[4]

Receptor tyrosine kinases: the main targets for new anticancer therapy. Drevs J,Medinger M,Schmidt-Gersbach C,et al. Current Drug Targets . 2003

[5]

Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. Malik SN,Brattain M,Ghosh PM,et al. Clinical Cancer Research . 2002

[6]

Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance. Freitas S,Moore DH,Michael H,et al. Clinical Cancer Research . 2003

[7]

The phosphatidylinositol 3- kinase AKT pathway in human cancer. Vivanco I,Sawyers CL. Nature Reviews Cancer . 2002

[8]

A retroviral oncogene,akt, encoding a Serine/Threonine kinase containing an SH2like region. Bellacosa A,Testa JR,Staal SP,et al. Science . 1991

[9]

Activation of Akt(protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Hutchinson J,Jin J,Cardiff RD,et al. Molecular and Cellular Biology . 2001

[10]

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Daveis MA,Koul D,Dhesi H,et al. Cancer Research . 1999

← 1 →