高脂血症与微循环功能障碍研究进展

被引：29

作者：

亚白柳 ^{[1
,2
]}

李林 ^{[1
]}

机构：

[1] 首都医科大学宣武医院药物研究室神经变性病教育部重点实验室

[2] 济宁医学院神经生物学研究所

来源：

医学综述 | 2011年 / 17卷 / 20期

关键词：

微循环; 高脂血症; 氧化应激; 炎症;

D O I：

暂无

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

100201 [内科学];

摘要：

高脂血症不仅可以导致大动脉形态和功能改变,还可以诱导微循环系统发生表型改变。这种变化主要表现为小动脉血管扩张受损、毛细血管灌流不足、小静脉黏附因子表达增加。内皮细胞、白细胞、血小板激活和免疫细胞源性细胞因子参与微循环系统对高脂血症的应答调节,表明高脂血症微循环系统的变化对大血管病变有显著影响。对高脂血症造成的微循环功能障碍和炎症进行早期干预,会有效降低缺血性疾病高致残率、致死率。

引用

页码：3041 / 3043

页数：3

共 9 条

[1]

Microcirculation and oxidative stress [J].

Crimi, E. ;

Ignarro, L. J. ;

Napoli, C. .

FREE RADICAL RESEARCH, 2007, 41 (12) :1364-1375

[2]

C-reactive protein and interleukin-6 in vascular disease: culprits or passive bystanders? [J].

Rattazzi, M ;

Puato, M ;

Faggin, E ;

Bertipaglia, B ;

Zambon, A ;

Pauletto, P .

JOURNAL OF HYPERTENSION, 2003, 21 (10) :1787-1803

[3]

Role of Interferon-γ in Hypercholesterolemia-Induced Leukocyte–Endothelial Cell Adhesion.[J].Karen Y. Stokes;E. Chris Clanton;Kris P. Clements;D. Neil Granger.Circulation: Journal of the American Heart Association.2003, 16

[4]

Involvement of oxidation-sensitive mechanisms in the cardiovascular effects of hypercholesterolemia [J].

Napoli, C ;

Lerman, LO .

MAYO CLINIC PROCEEDINGS, 2001, 76 (06) :619-631

[5]

Fluvastatin therapy improves microcirculation in patients with hyperlipidaemia [J].

Haak, E ;

Abletshauser, C ;

Weber, S ;

Goedicke, C ;

Martin, N ;

Hermanns, N ;

Lackner, K ;

Kusterer, K ;

Usadel, KH ;

Haak, T .

ATHEROSCLEROSIS, 2001, 155 (02) :395-401

[6]

NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion [J].

Stokes, KY ;

Clanton, EC ;

Russell, JM ;

Ross, CR ;

Granger, DN .

CIRCULATION RESEARCH, 2001, 88 (05) :499-505

[7]

Endothelial dysfunction is associated with cholesterol levels in the high normal range in humans [J].

Steinberg, HO ;

Bayazeed, B ;

Hook, G ;

Johnson, A ;

Cronin, J ;

Baron, AD .

CIRCULATION, 1997, 96 (10) :3287-3293

[8]

SELECTIVE LOSS OF MICROVASCULAR ENDOTHELIAL FUNCTION IN HUMAN HYPERCHOLESTEROLEMIA [J].

GILLIGAN, DM ;

GUETTA, V ;

PANZA, JA ;

GARCIA, CE ;

QUYYUMI, AA ;

CANNON, RO .

CIRCULATION, 1994, 90 (01) :35-41

[9]

Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis..Kawashima S;Yokoyama M;.Arteriosclerosis; Thrombosis; and Vascular Biology.2004, 06

← 1 →