狄诺塞麦:治疗绝经期女性骨质疏松的新希望

被引：7

作者：

郑振峰

林珊

机构：

[1] 天津医科大学总医院肾内科

来源：

国际内分泌代谢杂志 | 2011年 / 03期

关键词：

狄诺塞麦; 骨质疏松; 骨密度; 绝经; 治疗;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

狄诺塞麦是目前用于治疗绝经期骨质疏松的第一种单克隆抗体药物。它能与细胞核因子-κB受体活化因子配体(RANKL)结合,通过抑制破骨细胞的产生、功能和存活,减少骨吸收达到治疗作用。临床试验显示,在绝经后骨质疏松妇女中,狄诺塞麦增加骨密度(BMD)和降低骨折风险的作用优于安慰剂和阿仑膦酸,不良反应与安慰剂和阿仑膦酸相当。药效经济学研究也显示出狄诺塞麦有更好的成本效益比,可替代现有治疗骨质疏松的口服药物。狄诺塞麦有希望成为治疗骨质疏松的新选择。

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