黑虎丹治疗兔骨关节炎的实验研究

被引：35

作者：

万荣

杨庆铭

邓廉夫

机构：

[1] 上海第二医科大学附属瑞金医院伤骨科研究所!上海,上海第二医科大学附属瑞金医院伤骨科研究所!上海,上海第二医科大学附属瑞金医院伤骨科研究所!上海

来源：

中国骨伤 | 2001年 / 02期

关键词：

骨关节炎; 软骨,关节; 细胞;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

目的　观察黑虎丹治疗骨关节炎 (OA)的效果及其对OA软骨细胞增殖和凋亡的影响。方法　 36只雄性新西兰大白兔切断左膝前、后交叉韧带及内侧半月板 ,建立兔OA模型。随机分为对照组和用药组 ,各 18只。对照组不用药 ;用药组术后第 13周起口服黑虎丹 1粒 /天。分别于术后第 16、2 0、2 4周处死动物 ,取股骨内髁及胫骨内侧平台软骨标本进行光镜、透射电镜、扫描电镜观察 ,采用免疫组化、末端原位标记分别观察软骨细胞增殖和凋亡状况。结果　用药组骨关节炎病理表现与对照组无显著差别 ,用药组软骨细胞增殖和凋亡指数随时间延长而减少 ,在术后 2 4周时均低于对照组。结论　长期服用黑虎丹能减少晚期OA软骨细胞的凋亡 ,并维持OA软骨细胞增殖和凋亡的平衡。

引用

页码：21 / 23+66

页数：4

共 10 条

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