肠道微生物稳态与肝癌关系的研究进展

被引：19

作者：

刘军灵 ^{[1
]}

秦斌 ^{[2
]}

郑振东 ^{[1
]}

机构：

[1] 解放军北部战区总医院(原沈阳军区总医院)全军肿瘤诊治中心

[2] 沈阳药科大学

来源：

中国肿瘤生物治疗杂志 | 2018年 / 25卷 / 11期

关键词：

肝细胞癌; 肠道微生物; 肠屏障; 肝-肠轴;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

肝细胞癌(hepatocellular carcinoma,HCC)是全球发病率和死亡率较高的恶性肿瘤之一。菌群平衡对于维持肠道和全身态的代谢与免疫非常重要,肠道微生物与肝细胞癌的形成密切相关。肠漏、菌群失衡、微生物代谢物及免疫抑制是导致肝细胞癌形成的主要机制。肠漏及微生物相关模式分子-Toll样受体促进肝细胞癌的发生发展;菌群失衡及菌群移位除了能引起晚期肝病的感染性并发症之外,还能使肝脏中产生慢性炎症;肠道菌群及代谢物还可影响细胞的分化;肠道菌群及代谢产物介导的免疫抑制也可促进肝细胞癌的发生。可通过靶向肠道菌群,如使用抗生素杀灭有害菌群,使用益生菌调节菌群平衡,使用药物改善肠漏,使用药物拮抗TLR等策略来抑制肝细胞癌的发生。肠道微生物稳态与肝癌的研究进展为有效预防和治疗肝癌提出了新的策略。

引用

页码：1185 / 1190

页数：6

共 14 条

[1]

Our Gut Microbiome: The Evolving Inner Self [J].

Kundu, Parag ;

Blacher, Eran ;

Elinav, Eran ;

Pettersson, Sven .

CELL, 2017, 171 (07) :1481-1493

[2]

Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study.[J].Veronika Fedirko;Hao Quang Tran;Andrew T. Gewirtz;Magdalena Stepien;Antonia Trichopoulou;Krasimira Aleksandrova;Anja Olsen;Anne Tj?nneland;Kim Overvad;Franck Carbonnel;Marie-Christine Boutron-Ruault;Gianluca Severi;Tilman Kühn;Rudolf Kaaks;Heiner Boeing;Christina Bamia;Pagona Lagiou;Sara Grioni;Salvatore Panico;Domenico Palli;Rosario Tumino;Alessio Naccarati;Petra H. Peet

[3]

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity [J].

Shalapour, Shabnam ;

Lin, Xue-Jia ;

Bastian, Ingmar N. ;

Brain, John ;

Burt, Alastair D. ;

Aksenov, Alexander A. ;

Vrbanac, Alison F. ;

Li, Weihua ;

Perkins, Andres ;

Matsutani, Takaji ;

Zhong, Zhenyu ;

Dhar, Debanjan ;

Navas-Molina, Jose A. ;

Xu, Jun ;

Loomba, Rohit ;

Downes, Michael ;

Yu, Ruth T. ;

Evans, Ronald M. ;

Dorrestein, Pieter C. ;

Knight, Rob ;

Benner, Christopher ;

Anstee, Quentin M. ;

Karin, Michael .

NATURE, 2017, 551 (7680) :340-+

[4]

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease [J].

Chu, Hiutung ;

Khosravi, Arya ;

Kusumawardhani, Indah P. ;

Kwon, Alice H. K. ;

Vasconcelos, Anilton C. ;

Cunha, Larissa D. ;

Mayer, Anne E. ;

Shen, Yue ;

Wu, Wei-Li ;

Kambal, Amal ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Ernst, Peter B. ;

Green, Douglas R. ;

McGovern, Dermot P. B. ;

Virgin, HerbertW. ;

Mazmanian, Sarkis K. .

SCIENCE, 2016, 352 (6289) :1116-1120

[5]

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis [J].

Tabibian, James H. ;

O'Hara, Steven P. ;

Trussoni, Christy E. ;

Tietz, Pamela S. ;

Splinter, Patrick L. ;

Mounajjed, Taofic ;

Hagey, Lee R. ;

LaRusso, Nicholas F. .

HEPATOLOGY, 2016, 63 (01) :185-196

[6]

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease [J].

Jiang, Changtao ;

Xie, Cen ;

Li, Fei ;

Zhang, Limin ;

Nichols, Robert G. ;

Krausz, Kristopher W. ;

Cai, Jingwei ;

Qi, Yunpeng ;

Fang, Zhong-Ze ;

Takahashi, Shogo ;

Tanaka, Naold ;

Desai, Dhimant ;

Amin, Shantu G. ;

Albert, Istvan ;

Patterson, Andrew D. ;

Gonzalez, Frank J. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) :386-402

[7]

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome [J].

Yoshimoto, Shin ;

Loo, Tze Mun ;

Atarashi, Koji ;

Kanda, Hiroaki ;

Sato, Seidai ;

Oyadomari, Seiichi ;

Iwakura, Yoichiro ;

Oshima, Kenshiro ;

Morita, Hidetoshi ;

Hattori, Masahisa ;

Honda, Kenya ;

Ishikawa, Yuichi ;

Hara, Eiji ;

Ohtani, Naoko .

NATURE, 2013, 499 (7456) :97-+

[8]

Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats [J].

Zhang, Hui-Lu ;

Yu, Le-Xing ;

Yang, Wen ;

Tang, Liang ;

Lin, Yan ;

Wu, Han ;

Zhai, Bo ;

Tan, Ye-Xiong ;

Shan, Lei ;

Liu, Qiong ;

Chen, Hai-Yang ;

Dai, Rong-Yang ;

Qiu, Bi-Jun ;

He, Ya-Qin ;

Wang, Chao ;

Zheng, Long-Yi ;

Li, Yu-Qiong ;

Wu, Fu-Quan ;

Li, Zhong ;

Yan, He-Xin ;

Wang, Hong-Yang .

JOURNAL OF HEPATOLOGY, 2012, 57 (04) :803-812

[9]

Hepatocellular carcinoma [J].

Forner, Alejandro ;

Llovet, Josep M. ;

Bruix, Jordi .

LANCET, 2012, 379 (9822) :1245-1255

[10]

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 [J].

Dapito, Dianne H. ;

Mencin, Ali ;

Gwak, Geum-Youn ;

Pradere, Jean-Philippe ;

Jang, Myoung-Kuk ;

Mederacke, Ingmar ;

Caviglia, Jorge M. ;

Khiabanian, Hossein ;

Adeyemi, Adebowale ;

Bataller, Ramon ;

Lefkowitch, Jay H. ;

Bower, Maureen ;

Friedman, Richard ;

Sartor, R. Balfour ;

Rabadan, Raul ;

Schwabe, Robert F. .

CANCER CELL, 2012, 21 (04) :504-516

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