急性脑梗死患者早期神经功能恶化与阿司匹林抵抗的关系

被引:23
作者
王庄
邱彩霞
晏玉奎
机构
[1] 湖州市中心医院神经内科
关键词
急性脑梗死; 早期神经功能恶化; 阿司匹林抵抗;
D O I
10.19485/j.cnki.issn1007-0931.2017.01.018
中图分类号
R743.33 [脑栓塞];
学科分类号
100204 [神经病学];
摘要
目的研究急性脑梗死患者早期神经功能恶化(END)与阿司匹林抵抗(AR)的关系。方法分析2014年9月—2015年12月于湖州市中心医院住院治疗的119例急性脑梗死患者的临床资料,测定血小板聚集功能,评价AR和神经系统功能,采用多因素Logistic回归模型分析END发生的影响因素。结果 119例急性脑梗死患者中发生END 26例,占21.84%。单因素分析显示,在END组患者中有AR、高血压史及糖尿病史者的比例高于非END组(均P<0.05)。多因素分析显示,AR(OR=3.06,95%CI:1.22~7.65)及高血压(OR=3.28,95%CI:1.03~10.53)是急性脑梗死患者发生END的危险因素(均P<0.05)。结论有高血压病史及AR的急性脑梗死患者发生END的风险相对较高。
引用
收藏
页码:70 / 72
页数:3
相关论文
共 9 条
[1]
脑梗死急性期血压变化特点及其与进展性脑梗死的关系 [J].
王惠 ;
马先军 .
卒中与神经疾病, 2015, 22 (04) :226-229
[2]
Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke [J].
Tanaka, Ryota ;
Ueno, Yuji ;
Miyamoto, Nobukazu ;
Yamashiro, Kazuo ;
Tanaka, Yasutaka ;
Shimura, Hideki ;
Hattori, Nobutaka ;
Urabe, Takao .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2013, 332 (1-2) :45-50
[3]
A contemporary viewpoint on 'aspirin resistance' [J].
Kuzniatsova, Nadzeya ;
Shantsila, Eduard ;
Blann, Andrew ;
Lip, Gregory Y. H. .
ANNALS OF MEDICINE, 2012, 44 (08) :773-783
[4]
Aspirin non-responder status and early neurological deterioration: A prospective study.[J].Jean-Marc Bugnicourt;Bertrand Roussel;Pierre-Yves Garcia;Sandrine Canaple;Chantal Lamy;Olivier Godefroy.Clinical Neurology and Neurosurgery.2010, 3
[5]
Hemodynamic Factors and Perfusion Abnormalities in Early Neurological Deterioration [J].
Alawneh, Josef A. ;
Moustafa, Ramez Reda ;
Baron, Jean-Claude .
STROKE, 2009, 40 (06) :E443-E450
[6]
Aspirin resistance [J].
Hankey, GJ ;
Eikelboom, J .
LANCET, 2006, 367 (9510) :606-617
[7]
A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease [J].
Gum, PA ;
Kottke-Marchant, K ;
Welsh, PA ;
White, J ;
Topol, EJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (06) :961-965
[8]
Prediction of early neurological deterioration using diffusion- and perfusion-weighted imaging in hyperacute middle cerebral artery ischemic stroke [J].
Arenillas, JF ;
Rovira, A ;
Molina, CA ;
Grive, E ;
Montaner, J ;
Sabin, JA .
STROKE, 2002, 33 (09) :2197-2203
[9]
Deteriorating ischemic stroke in 4 clinical categories classified by the Oxfordshire Community Stroke Project [J].
Tei, H ;
Uchiyama, S ;
Ohara, K ;
Kobayashi, M ;
Uchiyama, Y ;
Fukuzawa, M .
STROKE, 2000, 31 (09) :2049-2054