装置影响昆明小鼠物体再认记忆

被引:3
作者
王超 [1 ]
江伟 [1 ]
黄德武 [2 ]
陶飞 [1 ]
陈贵海 [1 ]
机构
[1] 安徽医科大学第一附属医院神经内科
[2] 安徽医科大学实验动物中心
关键词
衰老; 行为; 记忆; 小鼠;
D O I
10.13610/j.cnki.1672-352x.2009.02.029
中图分类号
S865.13 [];
学科分类号
摘要
在3种试验装置(Y形、方形及矩形)中检测昆明小鼠新物体再认能力的年龄及性别效应。结果表明,10min延迟试验中3个装置都没有检测到年龄和性别差异;24h延迟试验中21月龄鼠较6月龄和12月龄鼠新物体再认能力下降,且主要归因于雌鼠,Y形装置检测的数据较其他2个装置更敏感和稳定。以上结果提示,老年昆明雌鼠有遥远新物体再认记忆减退,Y形装置最敏感。
引用
收藏
页码:214 / 217
页数:4
相关论文
共 8 条
[1]
Age-related learning and memory impairments in adult-onset hypothyroidism in Kunming mice.[J].Hui Tong;Gui-Hai Chen;Rong-Yu Liu;Jiang-Ning Zhou.Physiology & Behavior.2007, 2
[2]
Age- and sex-related disturbance in a battery of sensorimotor and cognitive tasks in Kunming mice [J].
Chen, GH ;
Wang, YJ ;
Zhang, LQ ;
Zhou, JN .
PHYSIOLOGY & BEHAVIOR, 2004, 83 (03) :531-541
[3]
Accelerated senescence prone mouse-8 shows early onset of deficits in spatial learning and memory in the radial six-arm water maze [J].
Chen, GH ;
Wang, YJ ;
Wang, XM ;
Zhou, JN .
PHYSIOLOGY & BEHAVIOR, 2004, 82 (05) :883-890
[4]
Environmental enrichment reduces the mnemonic and neural benefits of estrogen [J].
Gresack, JE ;
Frick, KM .
NEUROSCIENCE, 2004, 128 (03) :459-471
[5]
A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy [J].
Duff, SJ ;
Hampson, E .
HORMONES AND BEHAVIOR, 2000, 38 (04) :262-276
[6]
Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition [J].
Dix, SL ;
Aggleton, JP .
BEHAVIOURAL BRAIN RESEARCH, 1999, 99 (02) :191-200
[7]
Estrogen replacement therapy and cognitive decline in older community women [J].
Matthews, K ;
Cauley, J ;
Yaffe, K ;
Zmuda, JM .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1999, 47 (05) :518-523
[8]
EFFECT OF COMBINED OR SEPARATE ADMINISTRATION OF PIRACETAM AND CHOLINE ON LEARNING AND MEMORY IN THE RAT [J].
ENNACEUR, A ;
DELACOUR, J .
PSYCHOPHARMACOLOGY, 1987, 92 (01) :58-67