细菌主动外排系统研究进展

被引:15
作者
贾蓓
钱元恕
机构
[1] 重庆医科大学附属第一医院!重庆
关键词
细菌耐药; 药物外排泵;
D O I
10.13461/j.cnki.wna.003386
中图分类号
R969 [临床药理学];
学科分类号
摘要
本文综述了目前发现的革兰氏阴性菌和阳性菌的主要外排系统的分子生物学特征和功能以及在耐药中的作用,并简介其生理功能,提出可能的对付其介导耐药的手段.
引用
收藏
页码:132 / 137
页数:6
相关论文
共 20 条
[1]  
A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of Gram-negative bacteria. Dinh T,paulsen IT,Saier MH. Journal of Bacteriology . 1994
[2]  
The SMR family:a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Paulsen IT,Skurray RA,Tam K,et al. Molecular Microbiology . 1996
[3]  
Multiple antibiotic resistance in Pseudomonas aeruginosa:evidence for involvement of an efflux operon. Poole K,Krebes CM,Neshat S. Journal of Bacteriology . 1993
[4]  
Multidrug resistance in Klebsiella pneumonia:a novel gene,ranA,conters a multidrug resistance phenotype in Escherichia coli. Geoge AM,Hall RM,Stokes HW. Microbiology . 1995
[5]  
Molecular characterization of the multidrug resistance proteins QacA and QacB:membrane topology and identifcation of residues involved in specificity for divalent cations. Paulsen IT,Brown MH,Littlejohn TG,et al. Proceedings of the National Academy of Sciences of the United States of America . 1996
[6]  
Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes——an analysis. Paulsen IT,Skurray RA. Gene . 1993
[7]  
EmrE,an Escherichia coli 12-kDa multidrug transporter,exchanges toxic cations and H~+and is soluble in organic solvents. Yerushalmi H,Lebendiker M,Schulchiner S. Journal of Biological Chemistry . 1995
[8]  
Two highly similiar multidrug transporters of Bacillus sublilis whose expression is differentiallyf regulated. Ahmed M,Lyass L,Markham PN,et al. Journal of Bacteriology . 1995
[9]  
Multidrug efflux pumps of Gram-negative bacteria. Nikaido H. Journal of Bacteriology . 1996
[10]  
Outer-member proteins responsible for multiple drug resistance in pseudomonas aeruginosa. Masuda N,Sakagawa E,Ohya S. Antimicrobial Agents and Chemotherapy . 1995