帕瑞昔布钠联合舒芬太尼用于全膝关节置换术后镇痛的临床研究

被引:23
作者
姚优修 [1 ,2 ]
王承海 [1 ]
王诗军 [1 ]
张树栋 [1 ]
邵伟 [1 ]
机构
[1] 烟台市烟台山医院
[2] 潍坊医学院
关键词
环氧化酶; 舒芬太尼; 全膝关节置换术; 术后镇痛;
D O I
暂无
中图分类号
R614 [麻醉学];
学科分类号
100217 [麻醉学];
摘要
目的观察帕瑞昔布钠联合舒芬太尼在全膝关节置换术后镇痛中的应用效果。方法 60例择期全麻下行人工全膝关节置换术患者,随机分为三组:舒芬太尼2μg/kg组(Ⅰ组),舒芬太尼2.5μg/kg组(Ⅱ),舒芬太尼2μg/kg+帕瑞昔布钠组(Ⅲ组)。记录术后2 h(T1)、6 h(T2)、12 h(T3)、24 h(T4)、36 h(T5)和48 h(T6)患者静止和运动VAS评分、Ramsay镇静评分、PCA按压次数、舒芬太尼用量、患者满意度及不良反应。结果与Ⅰ组比较,Ⅲ组T4~T6静止VAS评分降低,T3~T6运动VAS评分降低(P<0.05);与Ⅱ组比较,Ⅲ组T4~T6静止VAS评分降低,T3~T4运动VAS评分降低(P<0.05)。T3~T6Ⅲ组PCA按压次数少于Ⅰ组和Ⅱ组;Ⅱ组术后各时点舒芬太尼用量高于Ⅲ组(P<0.05)。Ⅱ组恶心呕吐的发生率高于Ⅰ和Ⅲ组(P<0.05)。Ⅲ组患者满意程度高于Ⅰ和Ⅱ组(P<0.05)。结论帕瑞昔布钠联合舒芬太尼用于患者膝关节置换术后镇痛,效果确切,优于单独应用舒芬太尼。
引用
收藏
页码:9 / 11
页数:3
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