Dystrophin基因第50和51号内含子部分核苷酸顺序分析

被引:2
作者
张成
柴建华
刘焯霖
梁秀龄
机构
[1] 中山医科大学神经病学教研室
[2] 上海复旦大学遗传研究所
关键词
碱基顺序; 重组; 基因;
D O I
暂无
中图分类号
学科分类号
摘要
Dystrophin基因第50和51号内含子是基因缺失热点之一。对其核昔酸顺序分析表明在50号内含子的305bp和51号内含子的402bp中的存在多个重复顺序,AT含量分别为73%和70%。讨论了Dystrophin基因可能缺失的机制,提出内含子中at富集区的重复顺序可能与DNA断裂有关。
引用
收藏
页码:268 / 271+318 +318-319
页数:7
相关论文
共 9 条
[1]  
Intragenic deletions in 164 boys with Duchenne muscualr dystrophy (DMD) studies with dystrophin cDNA. Upadhyaya M,Smith RA,Thomas NST,et al. Clinical Genetics . 1990
[2]  
Correlation of clinical and deletion data in Duchenne and Pecker muscular dystrophy. Hodgson S,Hart K,Abbs S,et al. Journal of Medical Genetics . 1989
[3]  
The molecular basis for Duchenne versus Pecker muscular dystrophy : correlation of severity with type of deletion. Koenig M,Beggs AH,Moyer M,et al. The American Journal of Human Genetics . 1989
[4]  
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein. Koenig M,Monaco AP,Kunkel LM,et al. Cell . 1988
[5]  
Correlation of nonsense sires in the lacl gene with specific codons in the nucleotide sequence. Miller JH. Coulondre C. Farahough PJ,et al. Nature . 1978
[6]  
Short, direct repeats at the breakpoints of deletions of the reti-noblastoma gene. Canning S,Dryja TP. Proceedings of the National Academy of Sciences of the United States of America . 1989
[7]  
Characterization of six partial deletions in the low density-lipoprotein (LDL) receptor gene causing familial hypercholesterolemia (FH). Langlois S. Kastelein JJ. Hayden MR,et al. The American Journal of Human Genetics . 1988
[8]  
242 breakpoints in the 200 kb deletion prone P20 region of the DMD gene widely spread. Blonden LA,Grootscholten PM,Den Dunnen JT. et al. Genomics . 1991
[9]  
DNA sequence with the chain terminating inhibitors. Sanger F,Nicklen S,Coulson AR,et al. Proceedings of the National Academy of Sciences of the United States of America . 1977