银杏二萜内酯葡胺注射液治疗急性缺血性脑卒中的认知功能、神经营养因子、S100B蛋白及肝肾功能的影响

被引：7

作者：

蒋炜丽

机构：

[1] 徐州医科大学附属医院急救中心

来源：

临床医药文献电子杂志 | 2019年 / 6卷 / 24期

关键词：

银杏二萜内酯葡胺; 急性缺血性脑卒中; 认知功能; BDNF;

D O I：

10.16281/j.cnki.jocml.2019.24.064

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

摘要：

目的探讨银杏二萜内酯葡胺注射液治疗急性缺血性脑卒中的认知功能、神经营养因子、S100B蛋白及肝肾功能的影响。方法选取70例急性缺血性脑卒中患者,区组随机化分为2组,对照组采用常规治疗,观察组在此基础上静脉滴注银杏二萜内酯葡胺注射液,比较入组后14±2天两组患者认知功能,神经营养因子BDNF,S100B蛋白水平和肝肾功能。结果两组患者治疗前的认知功能评分,BDNF,S100B蛋白和肝肾功能均无显著性差异(P>0.05),经治疗后两组患者的MMSE评分,MoCA评分和BDNF均升高,且观察组显著高于对照组(P<0.05),两组患者的S100B蛋白均降低,且观察组降低程度高于对照组(P<0.05)。两组患者治疗前后肝肾功能无显著差异(P>0.05)。结论急性缺血性脑卒中患者加用银杏二萜内酯葡胺注射液治疗可以提高认知功能,改善神经影响因子BDNF和S100B蛋白水平,且对肝肾功能无严重影响。

引用

页码：81 / 83

页数：3

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