人白细胞抗原-DRB1等位基因与中国西部泡状棘球蚴病易感性的研究

被引：7

作者：

李富荣

石佑恩

史大中

DA Vuitton

PS Craig

机构：

[1] 深圳市人民医院!,同济医科大学寄生虫学教研室,兰州医学院寄生虫学教研室,UniversitｄｅＦｒａｎｃｈｅcomt!France,DivisionofBiological!theUniversityofSalford,UK

来源：

中华医学杂志 | 2000年 / 06期

关键词：

HLA-DR抗原; 棘球蚴病; 聚合酶链反应;

D O I：

暂无

中图分类号：

R532.32 [棘球蚴病（包虫病）];

学科分类号：

摘要：

目的　了解人白细胞抗原 (HLA) DRB1等位基因与泡球蚴病相关性 ,阐明泡球蚴病的免疫学发病机制 ,探寻泡球蚴病的易感基因或抗病基因提供线索。方法　应用PCR/SSP技术 ,对中国西部甘肃省漳县、岷县泡球蚴病高流行区 4个乡的 35例患者和 10 4例正常人群进行了HLA DRB1基因型分析。结果　患者组HLA DRB1 0 40x基因频率为 2 6 % (18/70 ) ,正常对照组为 10 % (2 0 /2 0 8)(RR =4.45 ,χ2 =13.6 7,P <0 .0 1,EF =0 .2 0 )。HLA DRB1 0 70 1基因频率 ,患者组为 3% (2 /70 ) ,正常组为 14% (2 9/2 0 8) ,(RR =0 .16 ,χ2 =6 .2 6 ,P <0 .0 5 ,PF =0 .30 )。其他等位基因频率在患者组与正常组间差异无显著意义 (χ2 =0 .0 3～ 1.87,P >0 .0 5 )。结论　HLA DRB1 0 40x基因与泡状棘球蚴病具有相关性 ,所调查地区泡球蚴病的高流行与遗传因素有关。HLA DRB1 0 70 1基因则对泡球蚴病感染有抵抗作用

引用

页码：13 / 15

页数：3

共 11 条

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