五种常用二代抗精神病药物对首发精神分裂症患者泌乳素的近期影响

被引：44

作者：

王厚亮 ^{[1
,2
]}

赵靖平 ^{[1
]}

韩洪赢 ^{[2
]}

温盛霖 ^{[2
]}

张俊成 ^{[2
]}

机构：

[1] 中南大学湘雅二院精神卫生研究所

[2] 中山大学附属第三医院精神科

来源：

中国神经精神疾病杂志 | 2015年 / 41卷 / 07期

关键词：

利培酮; 奥氮平; 帕利哌酮; 喹硫平; 齐拉西酮; 泌乳素;

D O I：

暂无

中图分类号：

R749.3 [精神分裂症];

学科分类号：

100204 [神经病学];

摘要：

目的探讨目前临床常用的5种二代抗精神病药物对首发精神分裂症患者血清泌乳素(prolactin,PRL)水平的近期影响。方法 250例首发精神分裂症患者随机分为5组,分别采用利培酮、奥氮平、帕利哌酮、喹硫平、齐拉西酮治疗6周,检测基线(入组时)和治疗每周末血清泌乳素水平,并在基线和治疗第6周末采用阳性与阴性症状量表(positive and negative symptom scale,PANSS)和副反应量表(treatment emergent symptom scale,TESS)评估各药物疗效与安全性。结果患者泌乳素水平经重复测量方差分析示,时间因素主效应、分组因素主效应和时间与分组的交互效应均具有统计学意义(均P<0.01)。其中第1周末时,利培酮组泌乳素水平均高于另外4组(P<0.05);第2、3、4、5周末时,利培酮组和奥氮平组泌乳素水平均高于其他3组(P<0.05);第6周末,利培酮组、奥氮平组和帕利哌酮组均高于其他2组(P<0.05),并且利培酮组和奥氮平组高于帕利哌酮组(P<0.05)。治疗前后PANSS量表的变化值在5组间有统计学差异(P<0.05),不良反应发生率无统计学差异(P>0.05)。结论抗精神病药物治疗使患者泌乳素水平逐渐增高;不同二代抗精神病药物对泌乳素的近期影响不同,利培酮和奥氮平在治疗早期就能明显升高泌乳素水平。

引用

页码：389 / 394

页数：6

共 14 条

[1]

Prolactin serum levels correlate with inflammatory status in drug-naïve first-episode schizophrenia.[J].Xueqin Song;Xiaoduo Fan;Jianjiang Zhang;Hui Zheng;Xue Li;Lijuan Pang;Xumei Chen;Wei Zhang;Amy Harrington;Douglas Ziedonis;Luxian Lv.The World Journal of Biological Psychiatry.2014, 7

[2]

Second-generation and newly approved antipsychotics, serum prolactin levels and sexual dysfunctions: a critical literature review [J].

De Hert, Marc ;

Detraux, Johan ;

Peuskens, Joseph .

EXPERT OPINION ON DRUG SAFETY, 2014, 13 (05) :605-624

[3]

The Effects of Novel and Newly Approved Antipsychotics on Serum Prolactin Levels: A Comprehensive Review [J].

Peuskens, J. ;

Pani, L. ;

Detraux, J. ;

De Hert, M. .

CNS DRUGS, 2014, 28 (05) :421-453

[4]

Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis [J].

Riecher-Roessler, A. ;

Rybakowski, J. K. ;

Pflueger, M. O. ;

Beyrau, R. ;

Kahn, R. S. ;

Malik, P. ;

Fleischhacker, W. W. .

PSYCHOLOGICAL MEDICINE, 2013, 43 (12) :2571-2582

[5]

Prolactin concentrations in newly diagnosed; antipsychotic-na?ve patients with nonaffective psychosis.[J].Clemente Garcia-Rizo;Emilio Fernandez-Egea;Cristina Oliveira;Azucena Justicia;Eduard Parellada;Miguel Bernardo;Brian Kirkpatrick.Schizophrenia Research.2011, 1

[6]

Hyperprolactinaemia in early psychosis-not only due to antipsychotics [J].

Aston, Jacqueline ;

Rechsteiner, Evelyne ;

Bull, Nadine ;

Borgwardt, Stefan ;

Gschwandtner, Ute ;

Riecher-Rossler, Anita .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (07) :1342-1344

[7]

Improvement in hyperprolactinemia and reproductive comorbidities in patients with schizophrenia switched from conventional antipsychotics or risperidone to olanzapine [J].

Kinon, Bruce J. ;

Ahl, Jonna ;

Liu-Seifert, Hong ;

Maguire, Gerald A. .

PSYCHONEUROENDOCRINOLOGY, 2006, 31 (05) :577-588

[8]

Serum prolactin levels in unmedicated first-episode and recurrent schizophrenia patients: a possible marker for the disease's subtypes [J].

Segal, M ;

Avital, A ;

Rojas, M ;

Hausvater, N ;

Sandbank, S ;

Liba, D ;

Moguillansky, L ;

Tal, I ;

Weizman, A .

PSYCHIATRY RESEARCH, 2004, 127 (03) :227-235

[9]

Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women [J].

Muck-Seler, D ;

Pivac, N ;

Mustapic, M ;

Crncevic, Z ;

Jakovljevic, M ;

Sagud, M .

PSYCHIATRY RESEARCH, 2004, 127 (03) :217-226

[10]

Prevalence of hyperprolactinemia in schizophrenic patients treated with conventional antipsychotic medications or risperidone 1 1 This work was sponsored by Eli Lilly and Company..[J].Bruce J Kinon;Julie A Gilmore;Hong Liu;Uriel M Halbreich.Psychoneuroendocrinology.2003,

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