雌激素对雌性大鼠糖脂代谢和心脏结构的影响

被引：8

作者：

刘梦兰

黄琼

薛一

张媛媛

李璐

刘云

机构：

[1] 南京医科大学第一附属医院老年医学科

来源：

南京医科大学学报(自然科学版) | 2014年 / 34卷 / 07期

关键词：

雌激素; 肥胖; 心脏彩超; HE染色;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

目的:探讨高脂饮食和雌激素对雌性大鼠糖脂代谢和心脏结构的影响。方法:测定高脂饮食、去势后高脂饮食及去势后注射雌激素并高脂饮食3组雌性大鼠的体重变化、腹腔内脂肪重量、血糖及血胰岛素水平、血清雌二醇及血脂水平。心脏彩超检测大鼠心脏结构相关指标,心脏组织HE染色后显微镜下观察组织变化。结果:雌激素水平与肥胖程度呈负相关,雌激素可降低大鼠空腹血糖,改善胰岛素抵抗,降低血清总胆固醇含量,保护心肌细胞减轻变性坏死。结论:雌激素可有效改善由肥胖所致的胰岛素抵抗和脂代谢异常,保护心脏的结构。

引用

页码：894 / 897+903 +903

页数：5

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