肾素血管紧张素系统阻断剂的肾保护作用

被引:42
作者
刘必成
李敏侠
机构
[1] 东南大学附属中大医院东南大学肾脏病研究所
关键词
D O I
暂无
中图分类号
R686 [筋腱、韧带、滑囊疾病及损伤];
学科分类号
100220 [骨科学];
摘要
<正>近年来大量研究揭示,体内肾素血管紧张素系统(RAS)过度激活在肾脏病慢性进展中发挥了十分重要的作用。以血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体拮抗剂(ARB)为代表的RAS阻断剂通过降低血压、减少蛋白尿、抑制肾脏纤维化和延缓肾功能进展而发
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共 7 条
[1]
Effects of ACE Inhibition versus Non-ACE Inhibitor Antihypertensive Treatment on Myocardial Fibrosis in Patients with Arterial HypertensionRetrospective Analysis of 120 Patients with Left Ventricular Endomyocardial BiopsiesEinfluss der ACE-Hemmung im Vergleich zu einer antihypertensiven Therapie ohne ACE-Hemmer auf die Myokardfibrose bei Patienten mit primärer arterieller Hypertonie. Eine retrospektive Analyse von 120 Patienten mit linksventrikulären Endomyokardbiopsien [J].
Christian G. Brilla ;
Heinz Rupp ;
Bernhard Maisch .
Herz, 2003, 28 (8) :744-753
[2]
Diverse effects of increasing lisinopril doses on lipid abnormalities in chronic nephropathies [J].
Ruggenenti, P ;
Mise, N ;
Pisoni, R ;
Arnoldi, F ;
Pezzotta, A ;
Perna, A ;
Cattaneo, D ;
Remuzzi, G .
CIRCULATION, 2003, 107 (04) :586-592
[3]
Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels [J].
Komine, N ;
Khang, S ;
Wead, LM ;
Blantz, RC ;
Gabbai, FB .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (01) :159-164
[4]
Functional evidence for a role of vascular chymase in the production of angiotensin II in isolated human arteries [J].
Richard, V ;
Hurel-Merle, S ;
Scalbert, E ;
Ferry, G ;
Lallemand, F ;
Bessou, JP ;
Thuillez, C .
CIRCULATION, 2001, 104 (07) :750-752
[5]
Effects of perindopril on renal histomorphometry in diabetic subjects with microalbuminuria: A 3-year placebo-controlled biopsy study.[J].A. Nankervis;K. Nicholls;G. Kilmartin;P. Allen;S. Ratnaike;F.I.R. Martin.Metabolism.1998,
[6]
Influence of connective tissue growth factor antisense oligonucleotide on angiotensin II-induced epithelial mesenchymal transition in HK2 cells.[J]..Acta Pharmacologica Sinica.2006, 08
[7]
肾脏固有细胞在肾脏结构重塑中的作用研究进展 [J].
刘必成 ;
张建东 .
中华肾脏病杂志, 2004, (05)