脂蛋白相关磷脂酶A2在动脉粥样硬化中的作用

被引：3

作者：

李宁 ^{[1
]}

顾水明 ^{[2
]}

魏盟 ^{[1
]}

机构：

[1] 上海交通大学附属第六人民医院心内科

[2] 上海市徐汇区中心医院心内科

来源：

国际心血管病杂志 | 2008年 / 04期

关键词：

脂蛋白相关磷脂酶A2; 炎症; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

摘要：

人血浆脂蛋白相关磷脂酶A2(Lp-PLA2)又称血小板活化因子乙酰水解酶(PAF-AH),主要由巨噬细胞合成和分泌。大部分Lp-PLA2与低密度脂蛋白结合,能水解灭活血小板活化因子,水解低密度脂蛋白上的氧化磷脂,生成溶血卵磷脂和氧化型游离脂肪酸,因此既有抗炎抗动脉粥样硬化,又有促炎促动脉粥样硬化的作用。近年来,越来越多的研究表明,Lp-PLA2具有促动脉粥样硬化作用,是心血管病的风险预测因子,可能成为心血管病新的治疗目标。

引用

页码：212 / 215

页数：4

共 7 条

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