p38丝裂原活化蛋白激酶信号转导对肿瘤细胞凋亡的调控

被引:17
作者
李琦
刘宁宁
范忠泽
机构
[1] 上海中医药大学附属普陀医院肿瘤科
基金
上海市自然科学基金;
关键词
肿瘤; 细胞凋亡; p38MAPK;
D O I
暂无
中图分类号
R285 [中药药理学];
学科分类号
100806 [中药药理学];
摘要
p38丝裂原活化蛋白激酶(p38MAPK)信号通路是丝裂原活化蛋白激酶(MAPK)家族的一条重要途径,可被多种细胞外刺激而激活,近年来研究发现在细胞凋亡中发挥重要作用。p38MAPK可通过活化半胱天冬氨酸蛋白酶(caspase)家族成员、调节Bcl-2家族成员的活性、活化p53、参与Fas-FasL通路等多种途径介导肿瘤细胞的凋亡过程。
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