p38丝裂原活化蛋白激酶信号转导对肿瘤细胞凋亡的调控

被引：17

作者：

李琦

刘宁宁

范忠泽

机构：

[1] 上海中医药大学附属普陀医院肿瘤科

来源：

国际肿瘤学杂志 | 2009年 / 03期

基金：

上海市自然科学基金;

关键词：

肿瘤; 细胞凋亡; p38MAPK;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

p38丝裂原活化蛋白激酶(p38MAPK)信号通路是丝裂原活化蛋白激酶(MAPK)家族的一条重要途径,可被多种细胞外刺激而激活,近年来研究发现在细胞凋亡中发挥重要作用。p38MAPK可通过活化半胱天冬氨酸蛋白酶(caspase)家族成员、调节Bcl-2家族成员的活性、活化p53、参与Fas-FasL通路等多种途径介导肿瘤细胞的凋亡过程。

引用

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