白藜芦醇抗癌机制中3条信号通路研究进展

被引:6
作者
金元宝
金刚
机构
[1] 深圳职业技术学院应用化学生物技术学院
关键词
白藜芦醇; NF-κB; IAPs; PI3K/AKT;
D O I
10.19405/j.cnki.issn1000-1492.2012.09.026
中图分类号
R285 [中药药理学];
学科分类号
100806 [中药药理学];
摘要
白藜芦醇具有抗氧化、抗心血管疾病、抗癌、抗菌等多种生物活性。白藜芦醇通过影响凋亡通路、核转录因子(NF-κB)通路,以及磷脂酰肌醇-3激酶/苏氨酸激酶(PI3K/AKT)或丝裂原活化蛋白激酶(MAPK)通路中一些蛋白质或者基因的表达,从而发挥抗肿瘤作用。
引用
收藏
页码:1113 / 1116
页数:4
相关论文
共 11 条
[1]
Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner [J].
Nakayama, Hiroshi ;
Yaguchi, Takahiro ;
Yoshiya, Shinichi ;
Nishizaki, Tomoyuki .
RHEUMATOLOGY INTERNATIONAL, 2012, 32 (01) :151-157
[2]
FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol [J].
Rakesh K. Srivastava ;
Terry G. Unterman ;
Sharmila Shankar .
Molecular and Cellular Biochemistry, 2010, 337 :201-212
[3]
Chemopreventive Potential of Resveratrol in Mouse Skin Tumors Through Regulation of Mitochondrial and PI3K/AKT Signaling Pathways.[J].Preeti Roy;Neetu Kalra;Sahdeo Prasad;Jasmine George;Yogeshwer Shukla.Pharmaceutical Research.2009, 1
[4]
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives [J].
Kundu, Joydeb Kumar ;
Surh, Young-Joon .
CANCER LETTERS, 2008, 269 (02) :243-261
[5]
Effects of Concord grape juice on cognitive and motor deficits in aging [J].
Shukitt-Hale, B ;
Carey, A ;
Simon, L ;
Mark, DA ;
Joseph, JA .
NUTRITION, 2006, 22 (03) :295-302
[6]
Resveratrol downregulates the constitutional activation of nuclear factor-κB in multiple myeloma cells, leading to suppression of proliferation and invasion, arrest of cell cycle, and induction of apoptosis [J].
Sun, CY ;
Hu, Y ;
Liu, XY ;
Wu, T ;
Wang, YD ;
He, WJ ;
Wei, WN .
CANCER GENETICS AND CYTOGENETICS, 2006, 165 (01) :9-19
[7]
Resveratrol as an anticancer nutrient: molecular basis, open questions and promises [J].
Signorelli, P ;
Ghidoni, R .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2005, 16 (08) :449-466
[8]
Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis [J].
Poussier, B ;
Cordova, AC ;
Becquemin, JP ;
Sumpio, BE .
JOURNAL OF VASCULAR SURGERY, 2005, 42 (06) :1190-1197
[9]
Effect of resveratrol in experimental osteoarthritis in rabbits [J].
Elmali, N ;
Esenkaya, I ;
Harma, A ;
Ertem, K ;
Turkoz, Y ;
Mizrak, B .
INFLAMMATION RESEARCH, 2005, 54 (04) :158-162
[10]
THE SIR2 FAMILY OF PROTEIN DEACETYLASES.[J].Gil Blander;Leonard Guarente.Annual Review of Biochemistry.2004, 1