实验性小鼠柯萨奇B3病毒心肌炎自然杀伤细胞活性和干扰素测定

被引:6
作者
沈茜
汪美先
章同华
机构
[1] 长海医院临床实验诊断科
[2] 第四军医大学分子病毒研究室
[3] 长海医院心血管内科
[4] 西安
关键词
柯萨奇病毒B; 心肌炎; 杀伤细胞,自然; 干扰素; 动物; 小鼠;
D O I
10.16781/j.0258-879x.1993.04.018
中图分类号
学科分类号
摘要
测定了BALB/c鼠柯萨奇B3病毒(Cox B3)心肌炎病理过程中脾NK细胞活性及血清、心肌组织匀浆中干扰素水平。在感染后的第3天,NK细胞活性及血清、心肌组织匀浆中干扰素滴度达高峰,并以较高水平维持到第7天。小鼠受染后3~7d心肌组织中病毒滴度亦达峰值。随着病毒从心肌中消失,NK细胞活性及干扰素滴度急剧降至对照组水平。实验结果提示:鼠Cox B3感染早期,体内NK细胞活性和干扰素滴度升高的主要作用是溶解病毒感染细胞、限制病毒复制。
引用
收藏
页码:344 / 347
页数:4
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