小剂量长效干扰素联合利巴韦林治疗肝移植术后丙肝复发

被引：4

作者：

范铁艳

陈虹

沈中阳

田彦

杨洋

机构：

[1] 武警总医院器官移植研究所

来源：

武警医学 | 2013年 / 24卷 / 06期

关键词：

肝移植术后; 丙型肝炎复发; 疗效;

D O I：

10.14010/j.cnki.wjyx.2013.06.026

中图分类号：

R657.3 [肝及肝管];

学科分类号：

摘要：

目的探讨肝移植术后丙肝复发患者接受小剂量长效干扰素联合利巴韦林治疗的疗效。方法我院2002-06至2012-04肝移植术后丙肝复发患者,接受聚乙二醇干扰素(派罗欣)90μg/周,2周后升至135μg/周,利巴韦林600 mg/d,抗病毒治疗6、12、24周时监测血HCV-RNA滴度、肝功能、血常规及临床表现。结果肝移植术后丙肝复发患者接受小剂量长效干扰素联合利巴韦林治疗共22例,其中早期病毒学应答率(early virological response,EVR)达90.9%,治疗结束病毒学应答率(end-of-treatment virological response,ETVR)100.0%,持续病毒应答率(sustained virological response,SVR)为81.8%。治疗24周后,患者胆碱酯酶的活性较治疗前显著升高(P=0.013)。血红蛋白、血小板及白细胞轻度降低分别占54.5%、68.2%和27.3%,未见严重的发热、皮肤损害及脱发。结论小剂量长效干扰素联合利巴韦林治疗肝移植术后丙肝复发的EVR、ETVR及SVR率较高,肝脏合成能力增强,不良反应轻微。

引用

页码：507 / 510

页数：4

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