(S)-α,α’-二苯基-2-吡咯烷甲醇的简便合成

被引：2

作者：

杨晓武

倪京满

王锐

潘鑫复

机构：

[1] 兰州大学生物系、化学系应用有机化学国家重点实验室!兰州，

来源：

高等学校化学学报 | 1997年 / 06期

关键词：

合成，（S）－α; α’-二苯基-2-吡咯烷甲醇; 唑烷酮;

D O I：

暂无

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of optically active α, α -diphenyl-2-pyrrolidinemethanol (1)starting from L-proline, based on different N-protections, was described. Different N-pro-tections had no effect on the optical purity of compound 1, but gave different chemical yields. The yield was the lowest when PhCH2, was employed for N-protection. An investiga-tion on the effect of N-protection on the chemical yield and the optical purity of compound 1led to a convenient preparation of the new chiral oxazolidinone 3. The structure of 3 was identified with 1H NMR, 13C NMR, MS and IR.

引用

页码：911 / 913

页数：3