TH基因修饰的胶质细胞脑内移植治疗帕金森病的实验研究

被引：4

作者：

刘俊

张可成

蔡文琴

机构：

[1] 第三军医大学附属新桥医院神经外科!重庆

[2] 第三军医大学基础医学部组织学与胚胎学教研室!重庆

来源：

第三军医大学学报 | 2001年 / 05期

关键词：

帕金森病; 基因治疗; TH基因;

D O I：

10.16016/j.1000-5404.2001.05.030

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

目的　通过exvivo途径 ,利用基因工程化细胞对酪氨酸羟化酶 (TH)基因在治疗帕金森病中的作用进行探讨。方法　将TH基因构建入逆转录病毒载体中 ,再将含重组DNA的病毒上清感染培养的星形胶质细胞移植入PD大鼠脑内 ,了解PD鼠旋转行为的改善情况。结果　TH基因治疗组PD鼠旋转行为改善明显。结论　TH对PD有明显的治疗作用。星形胶质细胞可作为有效的基因工程细胞

引用

页码：556 / 558

页数：3

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